A recent article at Sciencedaily called Bioengineers Devise ‘Dimmer Swith’ To Regulate Gene Expression In Mammal Cells discusses new technology being developed that combined a targeted DNA repressor protein, and a custom-designed RNAi strand. The repressor is thought to prevent most transcription, but in the event not all genes are repressed, the RNAi is thought to hunt out those transcripts, and destroy them.
Another chemical called Isopropyl-â-thiogalactopyranoside acts as a “dimmer” that can block the repressor protein. Thus by altering the amount of this chemical, repressor and RNAi, they can regulate a gene’s expression. Cool.